In January 1971, the hospital situated Northbay Boulevard, Balut, Tondo, Manila started as the Tondo Annex of the Jose R. Reyes Memorial Hospital. By The Virtue of the Republic Act 6375 on August 16, 1971 (An act creating Tondo General Hospital and Medical Center), the ownership and possession of a lot, building, and other physical plants, equipment, tools, implements, records, funds, appropriations and personnel were transferred to the Hospital Board in the nameof the Tondo General Hospital and Medical Center.

         It was established and operated in and for the District of Tondo, City of Manila as a non-profit public institution and its purpose being primarily to give free in-patient and out-patient medical care to as many residents of the District of Tondo. Under this Act, the hospital shall have a bed capacity of not less than one hundred (100). Ninety percent of which shall be devoted exclusively to charity patients. On January 30, 1987, Executive Order No. 119 was passed reorganizing the Ministry of Health and its attached agencies. Tondo General Hospital and Medical Center created as a government corporation under R.A. 6375 was dissolved and all its assets, liabilities, properties and personnel were transferred to Tondo Medical Center under the Department of Health.

         Now, it has an authorized bed capacity of 300 and departmentalized services consisting of Anaesthesiology, Internal Medicine, Pediatrics, Obstetrics and Gynecology, Surgery, Optha, ENT, Family Medicine, Physical Medicine and Rehabilitation, Dermatology and Venereology, Radiology, Pathology and Acute Psychiatric Unit. Furthermore, the hospital caters to the health needs of both in-patients and out-patients along residential and industrial areas not only in Tondo but also from Caloocan, Malabon, Navotas, Valenzuela (CAMANAVA) and some parts of Bulacan. The Hospital is Philhealth accredited with all major departments accredited by their medical societies. The hospital is also a key player of DOH programs and continuous to be an effective partner with local government units in providing health care.

         To this day, Tondo Medical Center is undergoing infrastructure expansion, improvement, capability enhancement and continues the tireless quest to reach the top of the ever-increasing demand for expertise, services and treatment facilities that provide the most comprehensive and the best possible patient care to the community it serves.